Guinea Pig Whole Blood
Cayman Chemical trnsVaccenIc ACD methyl S
A histamine H1 receptor antagonist (Ki 2.3 nM) and first generation antihistamine competes with [3H]diltiazem for binding to the benzothiazepine site on rat cardiomyocytes (Ki 1.08 nM) decreases negative inotropic activity in isolated guinea pig left atria by 76 (EC50 250 nM) decreases negative chronotropic activity in guinea pig spontaneously beating isolated right atria by 48
Cayman Chemical compre Faty ACD Meth 1mL
A dual inhibitor of PI3K and mTOR (IC50s 3 4 12 16 and 16 nM for PI3Ka PI3KB PI3K and PI3KY respectively) inhibits proliferation of PC3 and MCF-7 1 cells (IC50s 330 and 180 nM respectively) reduces tumor volume in PC3 and MCF-7 1 mouse xenograft models at 10 mg/kg per day
Cayman Chemical PalmItoleIc ACD methyl STR
A broad-spectrum triazole fungicide inhibits the conversion of lanosterol to ergosterol leading to fungal cell membrane disruption inhibits S cerevisiae but not rat liver microsomal cytochrome P450 (IC50s 0 04 and 200 UM respectively) inhibits the growth of T deformans and R stolonifer (EC50s 0 073 and 4 6 Ug/ml respectively) as well as A niger M fructigena S nodorum T harzanium R solani and S rolfsii from 0 1 to 5 ppm increases the weight of seminal vesicles and vas deferens as well as the percentage of sperm with abnormal tail morphology and decreases the plasma concentration of estradiol in male rats at 4 mg/kg increases production of ROS the number of DNA mutations and the incidence of tumor formation in mouse liver
Cayman Chemical PalmItoleIc ACD methyl STR
A prodrug form of imidaprilat inhibits swine renal cortex ACE activity in vitro (IC50 9 9 UM) inhibits the angiotensin I-induced pressor response in normotensive rats decreases blood pressure in spontaneously hypertensive and 2K-1C renal hypertensive rats at 2 mg/kg decreases stroke incidence and increases survival in stroke-prone spontaneously hypertensive rats fed a high-salt diet reduces urinary albumin excretion in a mouse model of streptozotocin-induced diabetes at 5 mg/kg
Cayman Chemical 13 ZDocosenoIc ACD methyl
The main component (80 ) of ivermectin binds to glutamate-gated chloride channels inducing irreversible channel opening ivermectin inhibits replication of SARS-CoV-2 in Vero/hSLAM cells
Cayman Chemical TaurochenodeoxycholIc ACD
A membrane-permeant fluorescent Na indicator dye increasing concentration of Na increases the ratio of excitation efficiency at 330-345 nm to that at 370-390 nm with emission collected at 450-550 nm
Cayman Chemical 11 ZVaccenIc ACD methyl S
A multiple kinase inhibitor blocking Met Tie2 VEGF2 TrkA TrkB and TrkC with IC50 values of 2 7 8 0 9 2 0 85 4 6 and 0 83 nM respectively orally bioavailable and penetrates the blood brain barrier suppressing the growth of subcutaneous and intracerebroventricular xenograft tumors in mice
Cayman Chemical GlycodeoxycholIc ACD MaxSpec
Immunogen Recombinant mouse Olig1 Host Rabbit Species Reactivity ( ) Human Mouse Rat Applications ICC IHC IP WB MW 27 kDa
Cayman Chemical BacTRIal Faty ACD Methyl E 1mL
A quassinoid with diverse biological activities active against the P falciparum strains HB-3 and Dd-2 in vitro (IC50s 0 003 and 0 037 g/ml respectively) inhibits radish seed germination by 88 when used at a concentration of 1 mM inhibits dihydrotestosterone-induced androgen receptor transcriptional activity (IC50 69 nM in a reporter assay) as well as the growth and colony formation of LNCaP and 22RV1 cells at 0 1 M reduces tumor volume in 22Rv1 LNCaP and VCaP CRPC mouse xenograft models at 2 mg/kg
Cayman Chemical VIldaglIptIn carboxylIc ACD
An inhibitor of VEGFR2 (IC50 0 0027 M for the human receptor) selective for human VEGFR2 over mouse VEGFR2 and human VEGFR1 and VEGFR3 (IC50s 1 5 1 7 and 1 1 M respectively) as well as 40-fold selective over B-RAF RET and Tie2 inhibits VEGF-induced proliferation of HUVECs (IC50 0 01 nM) inhibits VEGF-induced increases in tissue weight and Tie2 levels in an angiogenesis chamber implant model in mice at 1 and 3 mg/kg per day inhibits primary tumor and metastasis growth in a B16 melanoma mouse model at 3 mg/kg per day
Cayman Chemical GlycoursodeoxycholIc ACD 250mg
A P-gp inhibitor inhibits the efflux of [3H]vinblastine by ABCB1 in Caco-2 colon cancer cells (EC50 0 05 UM) inhibits the efflux of rhodamine-123 and calcein-AM by BCRP and MRP1 in MDCK cells (EC50s 73 and 9 3 UM respectively) enhances growth inhibition of MCF-7/ADR breast cancer cells at 2 or 20 UM when used in combination with doxorubicin in vitro but does not alter the effectiveness of doxorubicin on growth inhibition in Caco-2 cells increases phosphorylation of p38 and JNK in Caco-2 cells and MCF-7/ADR cells when used at a concentration of 20 UM
Cayman Chemical ChenodeoxycholIc ACD 3Glucu
A chalcone and flavonoid with diverse biological activities inhibits a-glucosidase UGT1A1 and UGT1A7 (IC50s 11 1 11 3 and 3 6 UM respectively) cytotoxic to K562 cells (IC50 2 77 UM) inhibits RANKL-induced osteoclastogenesis of isolated mouse BMDMs at 5 Ug/ml
Cayman Chemical 4AmInobenzylphosphonIc ACD
An iridoid glucoside inhibits the activities of COX-1 and COX-2 by 37 and 48 respectively at 258 UM inhibits proliferation of AGS gastric SF-268 CNS HCT116 colon NCI H460 lung and MCF-7 breast cancer cells at 129 UM reduces carrageen-induced paw edema and TPA-induced ear dema in mice reduces increases in MDA levels and ROS production in isolated brain mitochondria isolated from as well as decreases infarct volume and neurological deficits in a rat model of MCAO-induced ischemia-reperfusion injury
Cayman Chemical PRfluoropropnsulfonIc ACD
A BTK inhibitor (IC50s 10-100 and C481S respectively) selective for BTK over EGFR (IC50 1-10 UM) decreases the number of Ki67-positive cells in MEC-1 CLL mouse xenograft models using MEC-1 cells that express either wild-type BTK or BTKC481S